New research suggests that individuals who stop using popular GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight far faster than those who end traditional diet and exercise plans.
Findings released in a major health publication points out that while overweight people often shed about a fifth of their total mass while on the medication, the weight returns at an estimated rate of 0.8 kg per month upon discontinuation.
"Individuals purchasing these drugs must be cognizant of the danger of fast rebound weight gain when the medication ends," stated lead investigator Dr. Susan Jebb.
This pace of regain implies a reversion to pre-treatment mass in about 18 months.
Comparing Therapies
The research, which looked at 37 of studies involving over 9,000 of patients, contrasted the outcomes of the injectable medications with other pills.
Scientists note that people who shed pounds through dieting usually experience a more gradual creep back—approximately 0.1 kg a month—once they finish.
Understanding the Rapid Rebound
Experts suggest the mode of action of the jabs is key to understanding the heightened regain.
The injections mimic a natural hormone called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of GLP-1 concentrations far above than the body's typical production may cause the body to produce less of its own natural hormone, and could reduce responsiveness to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this hormone supplement means hunger is uncontrolled, making binge eating much more probable."
A Lifelong Issue?
Health authorities recommend the injections for people with weight-linked medical conditions, alongside recommended lifestyle changes.
Many experts contend that, given the high risk of weight regain, the therapy should be considered ongoing.
This view is supported by pharmaceutical companies, who state that the results "highlight the long-term character of obesity," akin to managing diseases like diabetes.
User Testimonies
Users who have stopped the jabs report a powerful resurgence of cravings.
"I experienced a switch flipping and I was suddenly starving," described one woman.
The struggle is compounded if individuals have not developed permanent dietary or behavioural changes during therapy.
Growing Use
Recent estimates suggest that millions of people in the UK have used these injections in the last 12 months, with desire continuing to grow.
- Use is more common among females compared to males.
- The 40s and 50s age group shows the highest usage rates.
- Many access the medications through private healthcare rather than public health services.
In conclusion, clinicians stress that while the jabs are potent agents for weight loss, they are not a magic solution and long-term success likely depends on ongoing behavioural management.
